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KMID : 0607520200280010036
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Korean Journal of Psychosomatic Medicine
2020 Volume.28 No. 1 p.36 ~ p.41
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A Retrospective Study on the Effect of 1-Year Clozapine Administration on Platelet Activity in Patients with Schizophrenia or Schizoaffective Disorder
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Jang Eun-Ja
Lee Jong-Wook
Kim Seung-Jun
Oh Hong-Seok
Lee Na-Hyun
Im Woo-Young
Kim Ji-Woong
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Abstract
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Objectives : Clozapine has been known to increase the possibility of developing cardio/cerebrovascular diseases, and the platelet activation has been deemed to be related to the occurrence of them. In author’s previous study, we observed the increase of platelet activity with short-term clozapine administration. This study was conducted, as a follow-up study, to investigate the effect of clozapine on the platelet activity when administered continuously for long-term period of time of 1 year.
Methods : The medical records of the patients with schizophrenia or schizoaffective disorder who were treated with clozapine for 1 year were retrospectively reviewed. The degree of platelet activation was assessed by measuring the mean platelet component.
Results : Total of 24 patients were enrolled. 9 of them (37.5%) were male and 15 of them (62.5%) were female. In the Wilcoxon sign-ranks test, no significant change was observed between the mean platelet factor values at the beginning and at the end of one year.
Conclusions : No significant changes of mean platelet activity were observed after continued administration of clozapine for 1 year. Considering the author’s previous findings that observed a prominent decrease of mean platelet component after short-term clozapine administration, the result of this study suggests the possibility that the activity of the platelet may change depending on the duration of the clozapine administration.
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KEYWORD
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Clozapine , Mean platelet component , Platelet activation , Metabolic side effects , Thromboembolic disease
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